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Zipsor Drug Interactions

A number of medications are known to interact with Zipsor. Problems may occur if the pain reliever is taken in combination with cyclosporine, ACE inhibitors, or certain diuretics. These drug interactions may increase your risk for developing potentially serious problems (such as kidney damage or internal bleeding) and decrease the effectiveness of the medications.

An Overview of Zipsor Interactions

Zipsor™ (diclofenac potassium) can potentially interact with several other medications. Some of these medicines that may lead to drug interactions with Zipsor include:
  • ACE inhibitors, including:



  • Angiotensin II receptor blockers (ARBs), such as:


  • Corticosteroids, including (but not limited to):
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
Several herbal and nutritional supplements can also interact with Zipsor and may increase the risk of bleeding. Examples of these include, but are not limited to:
5 Common Pain Medication Fears

Zipsor Medication Information

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