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Xodol Warnings and Precautions

It's important to be aware of warnings and precautions with Xodol to avoid potential problems. For example, the drug may pose a special danger to people with lung problems or kidney or liver disease. In addition, people with hypothyroidism or an enlarged prostate may not be able to take Xodol. Warnings and precautions also apply to people with certain allergies.

Xodol: What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to taking Xodol™ (hydrocodone/APAP) if you have:
  • A history of drug or alcohol dependence
  • A head injury or high intracranial pressure
  • Severe abdominal (stomach) pain
  • Hypothyroidism
  • Addison's disease
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • An enlarged prostate (benign prostatic hyperplasia, or BPH)
  • Lung disease of any sort
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Xodol Warnings and Precautions

Precautions and warnings to be aware of prior to taking Xodol include the following:
  • The medication contains quite a bit of acetaminophen (Tylenol®). Taking too much Xodol, or taking Xodol in combination with other products that contain acetaminophen, can cause severe liver problems or even death due to Tylenol poisoning. Xodol may not be a good choice for people who already have liver disease.
  • Xodol is a narcotic medication with significant potential for abuse. It is not a good choice for people who have a history of alcohol or drug abuse. Do not take the drug more frequently, longer, or at a higher dose than prescribed. If you feel you may be developing a problem with Xodol abuse, please seek help from your healthcare provider.
  • The medication can cause slow and irregular breathing. In severe situations, this may be life-threatening. This may be especially dangerous in people with lung problems.
  • The medication can cause problems in people with head injuries or high intracranial pressure. Xodol should only be used with extreme caution in such circumstances.
  • Do not drive or operate heavy machinery until you know how Xodol affects you. Your reflexes and reaction times may be significantly affected, even if you feel fine.
  • Xodol can interfere with the diagnosis of many conditions that cause severe abdominal (stomach) pain.
  • Xodol can potentially interact with several other medications (see Xodol Drug Interactions).
  • Like any other narcotic, Xodol can cause dizziness and drowsiness, and may increase the risk of falls in elderly people.
  • Check with your healthcare provider before taking the drug if you have hypothyroidism, Addison's disease, an enlarged prostate, or kidney disease, as Xodol may not be the best choice for you.
  • Narcotics such as Xodol are likely to cause constipation. This side effect does not go away as you continue to take the drug. Usually, laxatives are necessary to treat and prevent constipation due to Xodol.
  • Xodol is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Xodol and Pregnancy).
  • Xodol passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Xodol and Breastfeeding).
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