Vicodin Drug Interactions

Taking certain medications in combination with Vicodin may result in dangerous (and even life-threatening) complications. These Vicodin drug interactions can increase your risk of side effects, such as difficulty breathing, memory loss, and drowsiness. Other interactions can also cause liver damage or even death. Alcohol, antihistamines, antipsychotic medications, and barbiturates are among the medications that can lead to Vicodin drug interactions.

 

Vicodin Drug Interactions: An Overview

Vicodin® (hydrocodone/APAP) can potentially interact with a number of other medications. Some of the medicines that may lead to Vicodin drug interactions include:
 
 
 
  • Barbiturates, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Benzodiazepines, such as:
 
 
  • Other acetaminophen products, including many prescription and non-prescription pain killers and cold or cough products
  • Other narcotics or opiates, such as morphine (MSContin®, MSIR®) or oxycodone (OyxIR®, OxyContin®)
  • Sleep medications.
     
(Vicodin Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;