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Vicodin Drug Interactions

Taking Vicodin in combination with a benzodiazepine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Vicodin with any benzodiazepines.
Other Acetaminophen Products
When taking Vicodin, you should limit your total daily dose of acetaminophen (from all sources combined) to no more than 4 grams (4000 mg) per day. The acetaminophen content of Vicodin is 500 mg per regular-strength Vicodin tablet, 750 mg per Vicodin ES® tablet, and 660 mg per Vicodin HP® tablet. Taking too much acetaminophen could lead to serious liver damage or even death.
Watch for any other sources of acetaminophen, including other prescription pain relievers and many over-the-counter products, such as Tylenol. To be safe, all other acetaminophen products should be avoided while you are taking Vicodin, unless you are extremely careful to limit your total acetaminophen use (from all sources added together) to 4 grams per day.
Other Narcotics or Opiates
Use extreme caution when combining Vicodin with other narcotics or opiates, as serious side effects could occur. You should only use these medications together with your healthcare provider's approval and supervision.
Sleep Medications
Vicodin can cause significant drowsiness, and combining it with a sleep medication could lead to dangerous effects. In general, Vicodin should not be used in combination with sleep medications, unless your healthcare provider specifically recommends that you do so.

Final Thoughts on Vicodin Drug Interactions

It is possible that not all Vicodin drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
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