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Vicodin Drug Interactions

Vicodin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Vicodin is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking Vicodin. Alcohol interacts with the narcotic component of Vicodin (hydrocodone), potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Alcohol also interacts with the acetaminophen (Tylenol®) component of Vicodin, increasing the risk of liver damage (see Tylenol and Alcohol for more information).
 
Antidepressant Medications
Combining an antidepressant with Vicodin could increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Vicodin with an antidepressant, as you may need to be monitored more closely and the dose of your medications may need to be adjusted.
 
Antihistamines
Many antihistamines cause significant drowsiness and can cause serious problems when used in combination with other medications that cause drowsiness, such as Vicodin. Check with your healthcare provider before taking Vicodin with an antihistamine, including non-prescription antihistamines.
 
Antipsychotic Medications
Combining an antipsychotic medication with Vicodin can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Vicodin with an antipsychotic medication.
 
Barbiturates
Combining a barbiturate with Vicodin can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Vicodin with a barbiturate.
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