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Ultram ER Side Effects

Notify your healthcare provider if you develop serious side effects of Ultram ER, such as seizures, hallucinations, or difficulty breathing. In many cases, however, people tolerate the medication well and any side effects that occur are typically easy to treat. Common side effects of this drug include constipation, nausea, and headaches. Other, less common side effects may include insomnia, diarrhea, and general weakness.

An Introduction to Ultram ER Side Effects

As with any medicine, Ultram® ER (tramadol ER) can cause side effects. However, not everyone who takes the medication will have problems. In fact, some people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Ultram ER. Your healthcare provider can discuss a more complete list of Ultram ER side effects with you.)

Common Side Effects of Ultram ER

Ultram ER has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking Ultram ER were documented and then compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients) or taking the short-acting version of tramadol.
Based on these studies, the most common bothersome (but not usually dangerous) side effects of Ultram ER included:
  • Constipation -- in up to 29.7 percent of people
  • Dizziness -- up to 28.2 percent
  • Nausea -- up to 26.2 percent
  • Drowsiness -- up to 20.3 percent
  • Headaches -- up to 15.8 percent.
Other common side effects (occurring in 5 to 12 percent of people) included:
  • Flushing of the skin
  • Itching
  • Vomiting
  • Insomnia
  • Dry mouth
  • Diarrhea
  • General weakness
  • Increased sweating
  • Loss of appetite
  • Low blood pressure when standing up.
It is important to understand that some of the percentages were taken from a study that used an Ultram ER dosage that is higher than the maximum recommended dosage (which probably increased the risk of side effects).
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Ultram ER Drug Information

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