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Ultram ER Drug Interactions

Taking Ultram ER with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous (see Tramadol and Serotonin Syndrome for more information).
Medications That Cause Drowsiness
Combining Ultram ER with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Ultram ER with such medications. Additionally, combining Ultram ER with some of these medications may increase the risk of seizures or serotonin syndrome (see Tramadol and Serotonin Syndrome and Tramadol and Seizures for a list of medications that can cause these problems when taken with Ultram ER).
Combining promethazine and Ultram ER can increase the risk of seizures or other side effects of Ultram ER. Check with your healthcare provider before combining these medications.
The liver metabolizes Ultram ER into a substance known as M1 that is responsible for much of the pain-relieving properties of Ultram ER. Quinidine interferes with the liver's ability to metabolize Ultram ER into M1, which might possibly make the medication less effective.
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Ultram ER Drug Information

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