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Ultram ER Drug Interactions

Ultram ER Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Ultram ER is combined with any of the drugs listed above.
You should avoid alcohol while taking Ultram ER. Alcohol interacts with Ultram ER, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing (see Tramadol and Alcohol for more information).
The combination of carbamazepine (a seizure medication) and Ultram ER should be avoided. Carbamazepine decreases the level of Ultram ER in the blood, making it less effective. Additionally, tramadol increases the risk of seizures, especially in people with a seizure disorder (see Tramadol and Seizures).
Taking cyclobenzaprine with Ultram ER increases the risk of seizures. This combination should be avoided if possible, especially in people who already have seizure problems.
Taking Ultram ER with dextromethorphan can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous (see Tramadol and Serotonin Syndrome for more information).
There have been rare reports of digoxin toxicity in people taking Ultram ER. Check with your healthcare provider before taking these medications together.
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