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Tylenol with Codeine Drug Interactions

Barbiturates
Combining a barbiturate with Tylenol with Codeine can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Tylenol with Codeine with a barbiturate.
 
Benzodiazepines
Taking Tylenol with Codeine in combination with a benzodiazepine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Tylenol with Codeine with any benzodiazepines.
 
Other Narcotics or Opiates
Use extreme caution when combining Tylenol with Codeine with other narcotics or opiates, as serious side effects could occur. You should only use these medications together with your healthcare provider's approval and supervision.
 
Other Products With Acetaminophen
When taking Tylenol with Codeine, you should limit your total daily dose of acetaminophen (from all sources combined) to no more than 4 grams (4000 mg) per day. The acetaminophen content of Tylenol with Codeine is 300 mg per tablet or 120 mg per teaspoonful (for the liquid). Taking too much acetaminophen could lead to serious liver damage or even death.
 
Watch for any other sources of acetaminophen, including other prescription pain relievers and many over-the-counter products, such as Tylenol. To be safe, all other acetaminophen products should be avoided while you are taking Tylenol with Codeine, unless you are extremely careful to limit your total acetaminophen use to 4 grams per day.
 
Sleep Medications
Tylenol with Codeine can cause significant drowsiness, and combining it with a sleep medication could lead to dangerous effects. In general, Tylenol with Codeine should not be used in combination with sleep medications, unless your healthcare provider specifically recommends that you do so.
 
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Drug Information -- Tylenol With Codeine

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