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Tylenol with Codeine Drug Interactions

Tylenol with Codeine Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Tylenol with Codeine is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking Tylenol with Codeine. Alcohol interacts with codeine, the narcotic component of Tylenol with Codeine, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Alcohol also interacts with the acetaminophen (Tylenol®) component of Tylenol with Codeine, increasing the risk of liver damage (see Tylenol and Alcohol for more information).
 
Antidepressants
Combining Tylenol with Codeine with an antidepressant could increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Tylenol with Codeine with an antidepressant, as you may need to be monitored more closely.
 
Antihistamines
Many antihistamines cause significant drowsiness and can cause serious problems when used in combination with other medications that cause drowsiness, such as Tylenol with Codeine. Check with your healthcare provider before taking Tylenol with Codeine with an antihistamine, including non-prescription antihistamines in allergy, cold/cough, sleep, and motion sickness products.
 
Antipsychotic Medications
Combining an antipsychotic medication with Tylenol with Codeine can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Tylenol with Codeine with an antipsychotic medication.
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Drug Information -- Tylenol With Codeine

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