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Tramadol Drug Interactions

Sibutramine
Taking tramadol with sibutramine can cause seizures or a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
St. John's Wort
Combining tramadol with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Triptans
Taking tramadol with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Tryptophan
Taking tramadol with tryptophan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms, as the condition can be dangerous.
 
Warfarin
There have been rare reports of a possible drug interaction between warfarin and tramadol that might increase your risk of bleeding. Check with your healthcare provider before combining these medications; you may need to be monitored more closely.
 

Final Thoughts on Interactions With Tramadol

It is possible that not all drug interactions with tramadol were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interaction that may apply to you.
 
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