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Tramadol Drug Interactions

Digoxin
There have been rare reports of digoxin toxicity in people taking tramadol. Check with your healthcare provider before taking these medications together.
 
Linezolid
Taking tramadol with linezolid can cause a group of symptoms called serotonin syndrome. Symptoms include:
 
  • Confusion
  • Hallucinations
  • A fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasms
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous (see Tramadol and Serotonin Syndrome for more information).
 
Medications That Cause Drowsiness
Combining tramadol with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking tramadol with such medications. In addition, combining tramadol with some of these medications may increase the risk of seizures or serotonin syndrome (see Tramadol and Serotonin Syndrome and Tramadol and Seizures for a list of medications that can cause these problems).
 
Promethazine
Combining promethazine and tramadol can increase the risk of seizures or other tramadol side effects. Check with your healthcare provider before taking these medications together.
 
Quinidine
The liver metabolizes tramadol into a substance known as M1, which is responsible for much of the drug's pain-relieving properties. Quinidine interferes with the liver's ability to metabolize tramadol into M1, which might possibly make tramadol less effective.
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