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Tramadol Drug Interactions

Tramadol Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when tramadol is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking tramadol. Alcohol interacts with the medication, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing (see Tramadol and Alcohol for more information).
 
Carbamazepine
The combination of carbamazepine (a seizure medication) and tramadol should be avoided. Carbamazepine decreases the level of tramadol in the blood, making it less effective. In addition, tramadol increases the risk of seizures, especially in people with a seizure disorder (see Tramadol and Seizures).
 
Cyclobenzaprine
Taking cyclobenzaprine with tramadol increases the risk of seizures. This combination should be avoided if possible, especially in people who already have seizure problems.
 
Dextromethorphan
Combining tramadol with dextromethorphan can cause a group of symptoms called serotonin syndrome. These symptoms include:
 
  • Confusion
  • Hallucinations
  • A fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasms
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous (see Tramadol and Serotonin Syndrome for more information).
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Tramadol Medication Information

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