Drug Interactions With Tramadol/Acetaminophen

A number of medicines may cause drug interactions with tramadol/acetaminophen, including narcotics or opiates, antihistamines, triptans, and certain antidepressants. These interactions could increase your risk for side effects (such as extreme drowsiness, confusion, or difficulty breathing) or cause a group of dangerous symptoms called serotonin syndrome. To help prevent negative tramadol/acetaminophen interactions, tell your healthcare provider about all other drugs you are taking.

 

Tramadol/Acetaminophen Drug Interactions: An Overview

Tramadol/acetaminophen (Ultracet®) can potentially interact with a number of other medications. Many of these interactions can be quite serious. Some of the medicines that may lead to tramadol/acetaminophen interactions include:
 
  • Alcoholic beverages
  • Antihistamines (including many allergy, sleep, and motion sickness medications)
  • Antipsychotics
  • Barbiturate medications, including, but not limited to:

 

    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Benzodiazepines, such as:

 

 

 

 
  • Narcotics or opiates, such as morphine (MS Contin®, MSIR®), oxycodone (OyxIR®, OxyContin®), or codeine
  • Other products that contain acetaminophen, including many prescription and non-prescription pain killers and cold or cough products
  • Sibutramine (Meridia®)
  • Sleep medications
  • SSRI or SNRI antidepressants, including:

 

 

 

 

 

 

(Drug Interactions With Tramadol/Acetaminophen Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;