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Drug Interactions With Tramadol/Acetaminophen

A number of medicines may cause drug interactions with tramadol/acetaminophen, including narcotics or opiates, antihistamines, triptans, and certain antidepressants. These interactions could increase your risk for side effects (such as extreme drowsiness, confusion, or difficulty breathing) or cause a group of dangerous symptoms called serotonin syndrome. To help prevent negative tramadol/acetaminophen interactions, tell your healthcare provider about all other drugs you are taking.

Tramadol/Acetaminophen Drug Interactions: An Overview

Tramadol/acetaminophen (Ultracet®) can potentially interact with a number of other medications. Many of these interactions can be quite serious. Some of the medicines that may lead to tramadol/acetaminophen interactions include:
  • Alcoholic beverages
  • Antihistamines (including many allergy, sleep, and motion sickness medications)
  • Antipsychotics
  • Barbiturate medications, including, but not limited to:


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:










What Your Pharmacist Wishes You Knew About Chronic Pain Medications

Tramadol/Acetaminophen Drug Info

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