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Drug Interactions With Tramadol/Acetaminophen

Benzodiazepines
Taking tramadol/acetaminophen in combination with a benzodiazepine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking tramadol/acetaminophen with any benzodiazepines.
 
Buspirone (BuSpar)
Taking tramadol/acetaminophen with buspirone can cause seizures or a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and diarrhea. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous. Talk to your healthcare provider before taking buspirone and tramadol/acetaminophen together.
 
Cyclobenzaprine (Flexeril)
Taking tramadol/acetaminophen with cyclobenzaprine can cause seizures or a group of dangerous symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together.
 
Meperidine (Demerol)
Taking tramadol/acetaminophen with meperidine can cause seizures or a group of dangerous symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together.
 
Mirtazapine (Remeron)
Taking tramadol/acetaminophen with mirtazapine can cause seizures or a group of dangerous symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking tramadol/acetaminophen with an MAOI can cause seizures or a group of dangerous symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together.
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Tramadol/Acetaminophen Drug Info

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