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Drug Interactions With Tramadol/Acetaminophen

Tramadol/Acetaminophen Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when tramadol/acetaminophen is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking tramadol/acetaminophen. Alcohol interacts with tramadol, the narcotic component of tramadol/acetaminophen, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Alcohol also interacts with the acetaminophen (Tylenol®) component of tramadol/acetaminophen, increasing the risk of liver damage (see Tylenol and Alcohol for more information). However, suddenly avoiding alcohol consumption while taking tramadol/acetaminophen can increase the risk of seizures. If you regularly drink alcohol, check with your healthcare provider before taking tramadol/acetaminophen.
 
Antihistamines
Many antihistamines cause significant drowsiness and can cause serious problems when used in combination with other medications that cause drowsiness, such as tramadol/acetaminophen. Check with your healthcare provider before taking tramadol/acetaminophen with an antihistamine, including non-prescription antihistamines in allergy, cold/cough, sleep, and motion sickness products.
 
Antipsychotic Medications
Combining an antipsychotic medication with tramadol/acetaminophen can increase your risk of side effects, such as seizures, drowsiness, confusion, memory loss, or difficulty breathing. Talk to your healthcare provider before taking tramadol/acetaminophen with an antipsychotic medication.
 
Barbiturates
Combining a barbiturate with tramadol/acetaminophen can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking tramadol/acetaminophen with a barbiturate.
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