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Talwin Nx Warnings and Precautions

Specific Precautions and Warnings for Talwin Nx

Some warnings and precautions to be aware of prior to taking this medicine include the following:
  • Talwin Nx should only be taken by mouth. Do not try to dissolve and inject the medication, either alone or with other substances. Talwin Nx contains naloxone, a drug that binds to and blocks opioid receptors in the body. The naloxone portion of Talwin Nx is not active if taken by mouth. However, if the medication is injected, naloxone becomes active, and could cause severe, life-threatening symptoms.
  • Do not drive, operate heavy machinery, or perform any activities requiring alertness until you know how Talwin Nx affects you. Talwin Nx can make you drowsy and significantly alter your reflexes and reaction times.
  • This drug can cause extremely slow, irregular, or shallow breathing, known as respiratory depression. Although generally rare with Talwin Nx use, respiratory depression is more likely to occur in people who already have breathing problems and in those who are taking other medicines that slow down breathing.
  • Talwin Nx is a narcotic medication and, like other narcotics, has the potential to cause dependence and lead to abuse. Take the medication exactly as prescribed; do not take it more frequently or at higher doses. Please seek help from a healthcare provider if you may be developing a problem with Talwin Nx abuse.
  • This medication may be particularly dangerous for people with high pressure around the brain, such as those with head injuries. It should be used with extreme caution in such people, and only if absolutely necessary.
  • Do not drink alcohol while taking Talwin Nx, as doing so could increase your risk for serious side effects, including extreme drowsiness, confusion, memory loss, or abnormally slow breathing. Talwin Nx should not be taken by anyone who is intoxicated on alcohol.
  • Talwin Nx may block the effects of other opioid medications, potentially causing serious withdrawal symptoms. If you take other opioids, your healthcare provider may need to wean you off these other medicines before starting you on Talwin Nx. 
  • Talwin Nx has been reported to cause hallucinations (seeing or hearing things that are not real), disorientation, and confusion. People who develop these symptoms should be monitored closely. In general, the symptoms usually resolve on their own within a few hours.
  • There have been reports of seizures occurring in people taking Talwin Nx. Make sure your healthcare provider knows if you have ever had a seizure before taking this medication.
  • Talwin Nx should be used cautiously in people with porphyria, a rare genetic condition associated with the abnormal production of heme (a substance found throughout the body, especially in the blood and bone marrow), as it may trigger an acute porphyria attack.
  • This medication can increase blood pressure, and should be used cautiously in people for whom an increase in blood pressure would be particularly dangerous.
  • People with liver disease may be more susceptible to Talwin Nx side effects and, therefore, should be treated cautiously with the medication.
  • Make sure your healthcare provider knows about all your other medical conditions before you take Talwin Nx. This medication should be used with caution in people with conditions such as:
  • Talwin Nx passes through breast milk. Therefore, if you are breastfeeding or plan to start, you should discuss this with your healthcare provider prior to taking the drug (see Talwin Nx and Breastfeeding).
  • Talwin Nx is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Talwin Nx and Pregnancy).
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