Pain Channel
Topics & Medications
Quicklinks
Related Channels

Talwin Nx and Pregnancy

As a pregnancy Category C medication, Talwin Nx (pentazocine/naloxone) may be used if the benefits to the mother outweigh the risks to the fetus. Animal studies on the individual components in this drug suggest that birth defects, increased fetal heart rate, and other serious complications could occur.

Can Pregnant Women Take Talwin Nx?

Talwin® Nx (pentazocine/naloxone) is a prescription medication used to treat moderate-to-severe pain. It is classified as a pregnancy Category C drug, which means it may not be safe for use during pregnancy, although the full risks are currently unknown.
 

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Talwin Nx is classified as a pregnancy Category C medicine.
 
Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
 
Talwin Nx is a combination medication. It contains two active ingredients: pentazocine and naloxone. Talwin Nx has not been adequately studied in pregnant women.
 
In animal studies, pentazocine caused a variety of birth defects when given in high doses as an injection under the skin (a subcutaneous injection) to pregnant hamsters. Naloxone has not been reported to cause problems when given to pregnant animals, but it has been shown to increase fetal heart rate and the number of fetal body movements in human studies.
 
The abuse of pentazocine during pregnancy has been associated with a variety of problems, such as:
 
  • Premature birth
  • Low birth weight
  • Reduced infant head size
  • Withdrawal symptoms in the newborn.
 
In many of the cases, women who abused pentazocine also abused other drugs, smoked cigarettes, or drank alcohol during their pregnancies. Therefore, it is difficult to say whether the problems observed were due to pentazocine, the other substances, or a combination of these factors.
 
Talwin Nx is a narcotic medication associated with the potential for abuse. It is known to cross the placenta to an unborn baby, and could cause dependence in the baby if used regularly during pregnancy. There have been reports of withdrawal symptoms occurring within 24 to 48 hours of birth in newborns whose mothers took pentazocine chronically during pregnancy. Symptoms of withdrawal in the newborns included:
 
  • Trembling
  • Changes in behavior, such as irritability, jitteriness, and hyperactivity
  • High-pitched crying
  • Sweating
  • Diarrhea
  • Vomiting.
 
However, a pregnancy Category C medicine may be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.
 
Therefore, a healthcare provider may recommend Talwin Nx if safer medications are not an option for treating moderate-to-severe pain in a pregnant woman. If your healthcare provider recommends long-term Talwin Nx use during pregnancy, your baby may need to be monitored more closely after birth.
 
Ways to Prep Your Kitchen to Eat Well During Cancer Treatment

Talwin Nx Drug Information

Referring Pages:
Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.