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Talacen Drug Interactions

Talacen Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Talacen is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using Talacen could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using this medication.
 
Alvimopan
The manufacturer of alvimopan recommends it not be used in people who have been taking opioid medications, including Talacen, for seven or more consecutive days immediately before alvimopan is to be started. This is because opioids can increase the risk for alvimopan side effects. Alvimopan is a medication used in people who have just had bowel surgery.
 
Anticholinergic Medications
Taking Talacen in combination with anticholinergic medicines could increase your risk for certain side effects, such as urinary retention (an inability to urinate) and severe constipation. Older adults may be more sensitive to these side effects. If you take these medicines together, talk to your healthcare provider if you experience constipation or problems urinating.
 
Azelastine Nasal Spray
Combining azelastine with narcotic pain medications, such as Talacen, may increase your risk for drowsiness and decrease your alertness. Talk with your healthcare provider before using these medications together.
 
Barbiturates
Barbiturates can increase how quickly your body processes acetaminophen (one of the active ingredients in Talacen), potentially making it less effective, and increasing the risk for liver damage. This is most important for people who take high doses of acetaminophen on a regular basis. Talk to your healthcare provider about this potential interaction if you take these medicines together.
 
Cholestyramine
Cholestyramine can bind to acetaminophen (one of the active components of Talacen) in the stomach and prevent it from being absorbed into your bloodstream. If you take these medicines together, make sure to take cholestyramine at least one hour after taking Talacen to help reduce the risk for this interaction.
 
Dasatinib
Taking dasatinib with Talacen may increase your risk for liver damage. If you take dasatinib, your healthcare provider may recommend you take less Talacen. Talk to your healthcare provider about this potential interaction if you take these medications together. 
 
Imatinib
Taking Talacen with imatinib may increase your risk for liver toxicity. This is because Talacen contains acetaminophen. It is generally recommended that people who take imatinib limit their acetaminophen use to no more than 1300 mg per day. Talk to your healthcare provider before using Talacen if you are receiving imatinib treatment.  
 
Medications That Cause Drowsiness
Talacen can cause significant drowsiness. Taking other medications that cause drowsiness while using Talacen may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before taking Talacen with other medications that can cause drowsiness. 
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining Talacen with an MAOI may lead to dangerously high blood pressure. Talk to your healthcare provider before using Talacen if you have taken an MAOI within the past 14 days.
 
Other Opioids
Talacen may block the effects of other opioid medications, which could make the other opioids less effective or cause withdrawal symptoms. Do not take Talacen with other opioids without your healthcare provider's approval.
 
Pegvisomant
Opioid medications, such as Talacen, can make pegvisomant less effective. Your healthcare provider may need to increase your pegvisomant dose if you take these medicines together.
 
Probenecid
Probenecid may increase blood levels of acetaminophen (one of the active components of Talacen), potentially increasing the risk for liver toxicity. Your healthcare provider may recommend a lower Talacen dose if you take these medicines together.
 
Sorafenib
Taking sorafenib with Talacen may increase your risk for liver damage. If you take these medicines together, your healthcare provider may recommend a lower Talacen dosage.
 
Thiazide Diuretics
If you take Talacen with a thiazide diuretic, your blood pressure may decrease too much. Your healthcare provider may choose to monitor you more closely for low blood pressure. Let your healthcare provider know if you experience dizziness or fainting, especially when standing, as this could be a sign of low blood pressure.
 
Certain Tobacco Products
Smoking tobacco products (such as cigarettes) can cause the body to remove Talacen faster than usual, potentially making it less effective. Make sure your healthcare provider knows if you smoke tobacco products during Talacen treatment.
 
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