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Sumatriptan/Naproxen Sodium

How Does Sumatriptan/Naproxen Sodium Work?

Sumatriptan/naproxen sodium, as the name implies, contains two separate medications -- sumatriptan (the same medication in Imitrex®) and naproxen sodium.
Sumatriptan belongs to a class of migraine medications called 5-HT agonists (or more commonly known as "triptans"). During a migraine headache, some of the blood vessels in the head become dilated (wider open than they usually are). Sumatriptan works by narrowing these blood vessels, helping them return to their normal state. This action helps to relieve migraine symptoms.
Naproxen sodium belongs to a group of medications known as nonsteroidal anti-inflammatory drugs (NSAIDS). It helps to relieve migraine pain by inhibiting the production of inflammatory chemicals known as prostaglandins.

Sumatriptan/Naproxen Sodium Effects

In one study, up to 65 percent of people with migraines had no (or mild) pain within two hours of taking sumatriptan/naproxen sodium, compared to just 55 percent of those taking sumatriptan alone, 44 percent of those taking naproxen sodium alone, or 28 percent of those taking a placebo (a "sugar pill" with no active ingredients). Additionally, sumatriptan/naproxen sodium was more effective for keeping people pain-free for 24 hours after taking a dose, compared to sumatriptan, naproxen sodium, or a placebo (in other words, it seemed to work better for preventing the migraine from returning).

When and How to Use Sumatriptan/Naproxen Sodium

Some general considerations for when and how to use sumatriptan/naproxen sodium include the following:
  • Sumatriptan/naproxen sodium comes in tablet form. It is taken by mouth as soon as possible once a migraine starts.
  • Swallow sumatriptan/naproxen sodium tablets whole with a drink of water or other fluids.
  • Sumatriptan/naproxen sodium can be taken with or without food. Because one of the components of the medication (naproxen sodium) can be irritating to the stomach, it may be a good idea to take sumatriptan/naproxen sodium with a little food (although this may not be possible due to nausea from the migraine).
  • Do not take two doses of sumatriptan/naproxen sodium within two hours of each other.
  • For sumatriptan/naproxen sodium to work properly, it must be taken as prescribed. The medication will not work if you stop taking it.
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Info on Sumatriptan/Naproxen Sodium

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