Pain Channel
Topics & Medications
Related Channels

Precautions and Warnings With Sumatriptan/Naproxen Sodium

Specific Warnings and Precautions for Sumatriptan/Naproxen Sodium

Some of the warnings and precautions to be aware of prior to using sumatriptan/naproxen sodium include the following:
If you have risk factors for heart disease (see Heart Disease Risk Factors), it is also strongly recommended that you take your first dose of sumatriptan/naproxen sodium in your healthcare provider's office. This is so your healthcare provider can monitor your heart.
  • In some cases, a stroke or transient ischemic attack can be misdiagnosed as a migraine. Your healthcare provider should make sure you are not having a stroke, especially if you have never had migraines in the past (see Stroke Symptoms for more information on the symptoms of a stroke).
  • Sumatriptan/naproxen sodium can cause blood vessels to spasm, including in the arms, legs, or colon (large intestine). This can cause a decrease in blood flow to these areas. Symptoms will vary based on the location. For example, a spasm in the colon can lead to severe abdominal pain or bloody diarrhea.
  • Taking sumatriptan/naproxen sodium with certain antidepressants, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can increase your risk of a dangerous group of symptoms called serotonin syndrome. Do not use sumatriptan/naproxen sodium with depression medications without first discussing it with your healthcare provider. Contact your healthcare provider immediately if you have any possible symptoms of serotonin syndrome, including:


    • Confusion
    • Seeing or hearing things that are not really there (hallucinations)
    • Fast heartbeat (tachycardia)
    • Feeling faint
    • Fever
    • Sweating
    • Muscle spasms
    • Difficulty walking
    • Diarrhea.


  • Sumatriptan/naproxen sodium can cause an increase in blood pressure. You should not take it if you have untreated high blood pressure (hypertension).
  • Sumatriptan/naproxen sodium can worsen congestive heart failure.
  • Because sumatriptan/naproxen sodium contains naproxen, a nonsteroidal anti-inflammatory drug (NSAID), it may increase the risk of bleeding, including dangerous internal bleeding. Be sure to let your healthcare provider know if you develop signs of bleeding in the digestive tract, such as:


    • Dark, tarry stools
    • Vomiting blood (which may sometimes look like coffee grounds)
    • Severe heartburn or indigestion
    • Bloody diarrhea.


  • Because sumatriptan/naproxen sodium contains naproxen, it can worsen (or even cause) kidney problems. If your kidneys are not functioning well, sumatriptan/naproxen sodium may not be a good choice for you.
  • Sumatriptan/naproxen sodium is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy. Talk to your healthcare provider before using sumatriptan/naproxen sodium if you are pregnant (see Treximet and Pregnancy for more information).
  • Sumatriptan/naproxen sodium passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about this.
  • If you have chest pain or jaw or neck tightness after taking sumatriptan/naproxen sodium, contact your healthcare provider immediately. These side effects are fairly common with sumatriptan/naproxen sodium and are not usually serious. However, your healthcare provider may need to make sure you are not having heart problems.
  • Tell your healthcare provider if you have liver problems (including liver failure or cirrhosis) or kidney problems (including kidney failure) before taking sumatriptan/naproxen sodium. This is because sumatriptan/naproxen sodium is removed from the body through the liver and kidneys.
  • There have been rare cases of seizures in people taking sumatriptan (one of the components of sumatriptan/naproxen sodium). If you have a history of seizures, talk to your healthcare provider before starting sumatriptan/naproxen sodium.
  • People with asthma may be more likely to be sensitive or allergic to naproxen, one of the components of sumatriptan/naproxen sodium.
  • Sumatriptan/naproxen sodium may cause changes in the eyes or vision problems. Tell your healthcare provider if you have eye or vision changes.
The Top 17 Side Effects of Chemotherapy

Info on Sumatriptan/Naproxen Sodium

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2018 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.