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Drug Interactions With Sumatriptan/Naproxen Sodium

Sumatriptan/Naproxen Sodium Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when sumatriptan/naproxen sodium is combined with any of the drugs listed above.
 
ACE Inhibitors
The naproxen in sumatriptan/naproxen sodium may make ACE inhibitors less effective for controlling blood pressure. Also, combining naproxen with an ACE inhibitor can increase the risk for kidney problems. Check with your healthcare provider before taking sumatriptan/naproxen sodium with an ACE inhibitor.
 
Aspirin (Bayer and Others)
In general, it is not recommended to take sumatriptan/naproxen sodium with aspirin. Both aspirin and naproxen (one of the components of sumatriptan/naproxen sodium) can increase the risk of bleeding, including dangerous internal bleeding. Check with your healthcare provider before combining sumatriptan/naproxen sodium with aspirin.
 
Certain Antidepressants
Taking sumatriptan/naproxen sodium with certain depression medications can cause a group of symptoms called serotonin syndrome. These symptoms include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
     
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
There are special warnings for MAOIs. Taking sumatriptan/naproxen sodium with a type A MAOI can greatly increase the amount of sumatriptan in your blood, increasing your chance of dangerous sumatriptan/naproxen sodium side effects. Do not take sumatriptan/naproxen sodium if you have used a type A MAOI within the last two weeks.
 
Although selegiline and rasagiline are usually considered to be type B MAOIs, they may also be MAO-A inhibitors when used at high doses. Ask your healthcare provider before taking sumatriptan/naproxen sodium with selegiline or rasagiline.
  
Diuretics
The naproxen in sumatriptan/naproxen sodium may make diuretics less effective for controlling blood pressure. Also, combining naproxen with a diuretic can increase the risk for kidney problems. Check with your healthcare provider before taking sumatriptan/naproxen sodium with a diuretic.
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Info on Sumatriptan/Naproxen Sodium

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