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Subutex Drug Interactions

Subutex Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Subutex is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using Subutex could increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using Subutex.
 
Benzodiazepines
Combining Subutex with a benzodiazepine may increase the risk for serious problems, including death, particularly in the case of abuse or overdose. Normally, there is a limit known as a "ceiling" as to how much Subutex can negatively affect breathing. However, benzodiazepines may increase this limit, allowing for dangerously slow or irregular breathing. Do not combine Subutex with a benzodiazepine without your healthcare provider's approval and supervision.
 
CYP 3A4 Inducer Medications
The liver breaks down Subutex using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Subutex with one of these drugs may decrease the level of Subutex in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure Subutex is working effectively if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Subutex using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Subutex with one of these drugs may increase the level of Subutex in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you take Subutex with a CYP 3A4 inhibitor.
8 Frequent Pain Syndromes

Subutex Medication Information

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