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Subsys Warnings and Precautions

People who are using Subsys for treating breakthrough cancer pain should be aware that this medication can cause serious complications, such as a slow heart rate and potentially life-threatening breathing problems. Other safety precautions with Subsys involve warnings about using this drug while pregnant or breastfeeding. In addition, it can cause negative interactions with alcohol and a number of medications.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to using Subsys® (fentanyl sublingual spray) if you have:
  • A history of drug or alcohol dependence or abuse
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A history of breathing problems, asthma, chronic obstructive lung disease (COPD), or other lung disease
  • A head injury, brain tumor, or increased pressure around the brain
  • Ever had a seizure
  • A slow heart rate or other heart problems
  • Low blood pressure (hypotension)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
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Subsys Medication Information

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