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When and How to Use It

Some general considerations to keep in mind during treatment with Subsys include the following:
  • This medication comes in the form of a liquid that is sprayed under the tongue. It is usually taken no more often than every four hours as needed for breakthrough pain.
  • Do not use more than two doses of this medication (30 minutes apart) for each breakthrough pain episode. Also, do not use it more than four times in a day (once you have found a successful dosage).
  • Continue to take your regularly scheduled, around-the-clock, opioid pain medication. Subsys alone will not control your pain.
  • Each Subsys dose comes in its own spray bottle, in a blister package. Keep the medication in the sealed blister unit until just before use.
  • This medication may be quite dangerous, and even fatal, if ingested by a child or someone for whom it was not prescribed. Store the unopened blisters in a safe place, out of the reach of children (see Subsys Storage and Disposal for more information).
  • Each package of Subsys contains everything you need to safely dispose of the used medication. Please follow the disposal instructions closely, as used bottles can pose a dangerous risk, especially for children. This is because the used bottles are no longer protected by the blister packaging, and they may still contain enough medication to cause a fatal overdose.
  • For the medication to work properly, it must be used as prescribed. Do not stop using this medication suddenly, or increase your dose without your healthcare provider's approval.
  • If you are unsure about anything related to your dosage of Subsys, please talk with your healthcare provider or pharmacist.
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Subsys Medication Information

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