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Sprix Drug Interactions

Using medications such as ACE inhibitors, muscle relaxants, or lithium in combination with Sprix may lead to negative drug interactions. Some of these reactions can alter the amounts of the medications in your blood, possibly decreasing the effectiveness of the drugs or causing potentially serious side effects. Make sure your healthcare provider is aware of any other medications or herbal supplements you are taking.

An Overview of Interactions With Sprix

Sprix™ (ketorolac nasal spray) may potentially react with a number of other medications. Some of the drugs that may lead to interactions with Sprix include but are not limited to:
  • Angiotensin II receptor blockers (ARBs), such as:


  • Corticosteroids, including (but not limited to):
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
5 Common Pain Medication Fears

Sprix Medication Information

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