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Savella Drug Interactions

When certain medications are taken with Savella, drug interactions may occur. Some of the medicines that may lead to negative interactions include triptans, clonidine, anticoagulant drugs, and certain antidepressants. These drug interactions could result in a group of potentially dangerous symptoms called serotonin syndrome; symptoms include hallucination, fast heartbeat, fever, muscle spasm, difficulty walking, and diarrhea.

Savella Interactions: An Overview

Savella® (milnacipran hydrochloride) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with Savella include but are not limited to:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)


  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Other SSRI or SNRI antidepressants, such as:
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Savella Medication Information

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