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Savella Drug Interactions

Savella Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Savella is combined with any of the drugs listed above.
 
Alcohol
You should not drink substantial amounts of alcohol while taking Savella. Heavy alcohol consumption may increase the risk of liver problems with Savella.
 
Clonidine
Savella may decrease the effectiveness of clonidine for lowering blood pressure. Check with your healthcare provider before taking these medications together.
 
Digoxin
In general, digoxin and Savella should not be taken together, as doing so increases the risk of low blood pressure (hypotension) and a rapid heart rate (tachycardia).
 
Epinephrine or Norepinephrine
Taking Savella with epinephrine or norepinephrine can cause high blood pressure (hypertension) or an irregular heart rhythm (arrhythmia). If you are taking Savella, your healthcare provider will need to take this into consideration before deciding to prescribe or administer epinephrine or norepinephrine.
 
Linezolid
Combining Savella with a linezolid can cause a group of symptoms called serotonin syndrome. This syndrome includes symptoms such as:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 
Intravenous Methylene Blue
Taking Savella with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. This drug should not be started in people taking IV methylene blue, but a person already taking Savella may be given IV methylene blue, if absolutely necessary, and only with very careful monitoring and only if Savella is stopped during treatment.
 
Lithium
Taking Savella with linezolid can increase your chance of developing dangerous side effects, including serotonin syndrome. This drug should not be started in people taking linezolid, but a person already taking Savella may be given linezolid, if absolutely necessary, and only with very careful monitoring and only if Savella is stopped during treatment.
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