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Ryzolt Warnings and Precautions

To minimize risks, the warnings and precautions for Ryzolt should be reviewed with your healthcare provider before starting the medication. For instance, check with your healthcare provider before taking this drug if you have certain health conditions, such as epilepsy, a head injury, or any lung disease. Safety concerns with Ryzolt also apply to people with certain allergies and women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider Before Taking Ryzolt?

You should talk with your healthcare provider prior to taking Ryzolt™ (tramadol ER) if you have:
  • A history of drug or alcohol dependence
  • Suicidal thoughts or behaviors
  • Seizures or epilepsy
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A head injury or high intracranial pressure
  • Severe abdominal (stomach) pain
  • Lung disease of any sort
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Ryzolt Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Ryzolt include the following:
  • Ryzolt should not be prescribed to people with suicidal tendencies. This medication can be lethal in the case of an overdose, especially if combined with alcohol.
  • Ryzolt can cause seizures, especially in people with a history of seizures, who are withdrawing from alcohol or narcotics, who have a head injury, or who take certain medications (see Tramadol and Seizures for more information).
  • Ryzolt has a significant potential for abuse. It is not a good choice for people who have a history of alcohol or drug abuse (see Tramadol Abuse). Do not take the drug more frequently, longer, or at a higher dose than prescribed. If you feel you may be developing a problem with Ryzolt, please seek help from your healthcare provider.
  • Ryzolt can cause a dangerous group of symptoms known as serotonin syndrome. This is most common when Ryzolt is combined with certain other medications (see Tramadol and Serotonin Syndrome for more information).
  • Ryzolt can cause slow and irregular breathing. In severe situations, this may lead to life-threatening complications. This may be especially dangerous in people with lung problems.
  • The medication can cause problems in people with head injuries or high intracranial pressure. Ryzolt should only be used with extreme caution in such circumstances.
  • Ryzolt can interfere with the diagnosis of many conditions that cause severe abdominal (stomach) pain.
  • Ryzolt can cause dizziness and drowsiness, and may increase the risk of falls in elderly people.
  • Do not drive or operate heavy machinery until you know how Ryzolt affects you. Your reflexes and reaction times may be significantly affected, even if you feel fine.
  • Ryzolt can potentially interact with several other medications (see Ryzolt Drug Interactions).
  • Ryzolt is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Tramadol and Pregnancy).
  • Ryzolt passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Tramadol and Breastfeeding).
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