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How Does It Work?

Ryzolt tablets are specially designed to release the medication continuously over a 24-hour period. Ryzolt contains tramadol, a drug that is classified as a "centrally acting opioid analgesic." This means that it works in the central nervous system (the brain and spinal cord), acts much like morphine in the body, and relieves pain. Much like morphine, Ryzolt binds to certain opioid receptors in the body known as μ ("mu") receptors.
Ryzolt also works a little like some antidepressant medications by inhibiting the reuptake of certain brain chemicals (serotonin and norepinephrine). Serotonin and norepinephrine are two of several chemicals used to send messages from one nerve cell to another. As a message travels down a nerve, it causes the end of the cell to release serotonin or norepinephrine. The serotonin or norepinephrine enters the gap between the first nerve cell and the one next to it.
When enough serotonin or norepinephrine reaches the second nerve cell, it activates receptors on the cell and the message continues on its way. The first cell then quickly absorbs any serotonin or norepinephrine that remains in the gap between the cells. This is called "reuptake."

When and How to Take Ryzolt

Some general considerations include the following:
  • Ryzolt comes in the form of extended-release tablets. It is usually taken once a day.
  • Ryzolt can be taken with or without food.
  • Breaking, dissolving, or crushing Ryzolt tablets can be very dangerous, as this will cause too much of the medication to be released too quickly.
  • Do not drink alcohol while taking this medication.
  • For the medication to work properly, it must be taken as prescribed. Do not increase your dose without your healthcare provider's approval. Do not suddenly stop taking Ryzolt, especially if you have taken it regularly for more than several weeks (see Tramadol Withdrawal).
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Ryzolt Medication Information

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