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Rybix ODT Side Effects

In clinical studies, up to 46 percent of people taking Rybix ODT developed constipation. Other common side effects included dizziness, headaches, and nausea, among others. Side effects of Rybix ODT tend to be minor and easy to treat. However, there are some reactions that require immediate medical attention, such as seizures, hallucinations, or hives.

An Introduction to Rybix ODT Side Effects

This medication is no longer available, as it has been discontinued by the manufacturer. Other tramadol products are still available. 
 
Just like any medicine, Rybix™ ODT (orally disintegrating tramadol) can cause side effects. However, not everyone who takes the medication will have problems. In fact, many people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Rybix ODT. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects of Rybix ODT

Tramadol (the active ingredient in Rybix ODT) has been studied extensively in clinical trials. In these studies, side effects occurring in the group of people taking the drug were documented and compared to those that occur in a similar group of people taking a placebo (a "sugar pill" with no active ingredients).
 
In these studies, the most common side effects included:
 
  • Constipation -- in up to 46 percent of people
  • Nausea -- up to 40 percent
  • Dizziness or a spinning sensation (vertigo) -- up to 33 percent
  • Headaches -- up to 32 percent
  • Drowsiness -- up to 25 percent
  • Vomiting -- up to 17 percent
  • Nervousness, shakiness, agitation, or other "overstimulation" problems -- up to 14 percent.
     
Other common reactions (occurring in 1 to 13 percent of people) included but were not limited to:
 
  • Itching
  • Weakness
  • Sweating
  • Indigestion or heartburn
  • Dry mouth
  • Diarrhea
  • Hot flashes or flushing
  • Confusion
  • Coordination problems
  • An unusual pleasant feeling (euphoria)
  • Small, pinpoint pupils
  • Sleeping problems
  • Abdominal pain (stomach pain)
  • Loss of appetite
  • Vision problems
  • Frequent urination or difficulty emptying the bladder fully
  • Menopause symptoms.
     
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Rybix ODT Medication Information

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