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Propoxyphene Dosage

When treating pain with propoxyphene, the standard recommended dosage is one propoxyphene napsylate tablet or one propoxyphene hydrochloride capsule every four hours as needed. However, your healthcare provider may adjust your dosage depending on how you respond to the medication and if you have certain medical conditions. Do not take more than 6 tablets or capsules in 24 hours.

An Introduction to Your Propoxyphene Dosage

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
The dose of propoxyphene (Darvon®, Darvon-N®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to propoxyphene
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Propoxyphene Dosing for Pain

The standard recommended dose of propoxyphene for treating pain is one propoxyphene napsylate tablet (100 mg) or one propoxyphene hydrochloride capsule (65 mg) every four hours as needed. Do not take more than 6 capsules or tablets in 24 hours.
One propoxyphene napsylate 100-mg tablet contains the same amount of propoxyphene as one 65-mg propoxyphene hydrochloride capsule, due to differences between the molecular weights of the active ingredients.
If you have been taking propoxyphene on a long-term basis, it is probably best to stop taking it gradually, under the supervision of a healthcare provider. Stopping it too quickly could lead to unpleasant (although rarely dangerous) withdrawal symptoms. Typically, decreasing the dosage by 25 to 50 percent each day works well.
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