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Propoxyphene Dosage

Propoxyphene Dosing for Special Situations

If you are taking certain other medications (known as CYP 3A4 inhibitors), you may need a lower propoxyphene dosage, as such medications slow the breakdown (metabolism) of propoxyphene by the liver (see Drug Interactions With Propoxyphene).
If your kidney or liver function is not optimal, your healthcare provider may decide to prescribe a lower dose of propoxyphene. Similarly, lower dosages are often recommended for elderly individuals, who may be more sensitive to the effects of propoxyphene.

General Information on Taking Propoxyphene

Some considerations for people taking propoxyphene include the following:
  • This medication comes in tablet form. It is taken by mouth every four hours as needed for pain. Do not ever take more than 6 tablets in 24 hours.
  • It is probably best to take propoxyphene with food, as it can be upsetting to the stomach.
  • Do not drink alcohol while taking this medication (see Darvon and Alcohol or Darvon-N and Alcohol).
  • For the medication to work properly, it must be taken as prescribed. Do not increase your dose without your healthcare provider's approval. Do not suddenly stop taking propoxyphene, especially if you have taken it regularly for more than several weeks (see Darvon Withdrawal or Darvon-N Withdrawal).
  • If you are unsure about anything related to your dosage of propoxyphene, please talk with your healthcare provider, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.
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Propoxyphene Drug Information

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