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Precautions and Warnings With Propoxyphene

Propoxyphene may cause low blood pressure, irregular breathing, and other potentially serious complications. Do not take more than the recommended amount of this medication, as an overdose can be lethal in a matter of minutes. Other precautions and warnings with propoxyphene include potential drug interactions and possible dangers of taking it while pregnant or breastfeeding.

What Should I Tell My Healthcare Provider Before Taking Propoxyphene?

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
 
You should talk with your healthcare provider prior to taking propoxyphene (Darvon®, Darvon-N®) if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • A history of drug or alcohol dependence
  • A bowel obstruction (blockage)
  • Low blood pressure (hypotension)
  • Lung disease of any sort
  • A head injury or high intracranial pressure
  • Asthma
  • Depression
  • Suicidal tendencies
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
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Propoxyphene Drug Information

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