Drug Interactions With Propoxyphene

Several substances, such as alcohol, beta blockers, and most antidepressants, can cause negative drug interactions with propoxyphene. Some of these interactions can increase your risk of serious complications, such as hallucinations, difficulty walking, and difficulty breathing. To avoid these problems, talk to your healthcare provider about any other medications you are taking, including nonprescription medicines and supplements.

An Overview of Propoxyphene Interactions

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
 
Propoxyphene (Darvon®, Darvon-N®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with this painkiller include:
 
 
 
 
 
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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