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Drug Interactions With Propoxyphene

Drug Interactions With Propoxyphene Explained

The following sections explain in detail the potentially negative interactions that can occur when propoxyphene is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking propoxyphene. Alcohol interacts with this pain reliever, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing (see Darvon and Alcohol or Darvon-N and Alcohol for more information).
 
Carbamazepine
Propoxyphene may increase the level of carbamazepine in your blood, perhaps increasing your risk of side effects of carbamazepine (including dangerous side effects). Your healthcare provider may recommend a different pain medication or may decide to decrease your carbamazepine dosage.
 
Certain Beta Blockers
Propoxyphene may increase the level of certain beta blockers in your blood. This may increase the chance of beta blocker side effects, such as low blood pressure (hypotension) or a low heart rate (bradycardia). Check with your healthcare provider before taking propoxyphene with one of these beta blockers.
 
CYP 3A4 Inducers
The liver metabolizes (breaks down) propoxyphene using an enzyme known as CYP 3A4. Some medications (known as CYP 3A4 inducers) increase the activity of this enzyme. Taking propoxyphene with a CYP 3A4 inducer may decrease the level of propoxyphene in the blood, possibly making it much less effective. Check with your healthcare provider before taking propoxyphene with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitors
The liver metabolizes (breaks down) propoxyphene using an enzyme known as CYP 3A4. Some medications (known as CYP 3A4 inhibitors) decrease the activity of this enzyme. Taking propoxyphene with a strong CYP 3A4 inhibitor may increase the level of propoxyphene in the blood, increasing the risk of dangerous propoxyphene side effects. Check with your healthcare provider before taking propoxyphene with a CYP 3A4 inhibitor.
Alternative Therapies for Pain Management

Propoxyphene Drug Information

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