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Effects of Pregabalin

Several studies have looked at pregabalin for treating seizures, nerve pain, and fibromyalgia.
Nerve Pain
Several studies have evaluated the effectiveness of pregabalin for treating nerve pain associated with spinal cord injury, diabetic peripheral neuropathy, or postherpetic neuralgia. In these studies, people who took the drug experienced less pain, compared to those not taking it. Some people experienced pain relief quickly -- within one week of starting pregabalin.
In two different studies, pregabalin was shown to be effective for treating pain due to fibromyalgia. Some people taking the drug experienced pain relief as quickly as within one week. In general, these studies found that 600 mg per day was not more effective (but caused more side effects) than 450 mg per day.
Pregabalin was evaluated in three studies for treating partial seizures in people with epilepsy. These studies included people who were already taking one to three other seizure medications and whose seizures were not adequately controlled. Depending on the dose, people who added pregabalin to their existing seizure medications decreased their number of seizures per month by up to 51 percent.

When and How to Take Pregabalin

Some general considerations for when and how to take pregabalin include the following:
  • The medication comes in capsule and liquid form. It is taken by mouth, usually two or three times daily.
  • Pregabalin can be taken with or without food. If the medication upsets your stomach, try taking it with food.
  • Pregabalin should be taken at the same times each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. Pregabalin will not work if you stop taking it.
  • Do not stop taking pregabalin without first discussing it with your healthcare provider (see Lyrica Withdrawal).
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