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Drug Interactions With Pregabalin

Some of the drugs that can potentially interact with pregabalin include anesthetics, barbiturates, and sleep medications. These drug interactions with pregabalin can potentially lead to serious side effects. Prior to starting pregabalin, it is important to consult your pharmacist or healthcare provider to be sure you understand the specific interactions that may apply to you.

An Overview of Drug Interactions With Pregabalin

Pregabalin (Lyrica®) can potentially interact with a few other medications. Some of these medicines that may lead to pregabalin interactions include:
  • Alcohol
  • Anesthetics
  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:



Alternative Therapies for Pain Management

Pregabalin (Lyrica) Drug Information

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