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What Is Pegloticase Used For?

How Does It Work?

Pegloticase works by lowering uric acid levels. This helps to treat gout, as this condition occurs when the levels of uric acid become so high that uric acid crystals form inside the joint. The medication lowers uric acid levels by causing a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.

Is Pegloticase Safe for Children?

Pegloticase has not been adequately studied in children or adolescents under the age of 18 years old. It is not known if pegloticase is safe or effective for children.

Is It Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend using pegloticase for something other than refractory gout (this would be known as an "off-label" use). Based on approved or off-label uses of other medications that are similar to pegloticase, it is predicted that pegloticase might possibly be prescribed off-label for the following purposes:
  • Preventing high uric acid levels due to cancer treatment
  • Preventing recurrent kidney stones in people with high uric acid levels.
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Pegloticase Drug Information

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