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Side Effects of Pegloticase

Although most people do not experience problems while receiving pegloticase, side effects are possible. Some of the common reactions to this drug include nausea, bruising, and vomiting. Serious problems have also been known to occur with this medication. Tell your healthcare provider immediately if you notice difficulty breathing, chest pain, or swelling of the mouth or throat, or other potentially dangerous allergic reactions.

An Introduction to Side Effects of Pegloticase

Just like any medication, pegloticase (Krystexxa®) can cause side effects. However, not everyone who receives the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with pegloticase. Your healthcare provider can discuss a more complete list with you.)

Pegloticase Side Effects to Report

Some possible side effects with pegloticase are potentially serious and should be reported immediately to your healthcare provider. Although generally rare, some of these side effects may actually be fairly common. These include but are not limited to:
  • Signs of heart failure (or worsening heart failure), such as rapid weight gain or shortness of breath
  • Signs of a serious allergic reaction or a less serious infusion reaction, such as:
    • An unexplained rash
    • Itching
    • Hives
    • Redness of the face
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing
    • Low blood pressure
    • Chest pain.
You should alert your healthcare provider to any signs or symptoms of such a reaction right away during your IV infusion. Your healthcare provider may need to slow the IV (or stop it altogether) and administer medications to control the reaction. Allergic reactions (especially those that involve low blood pressure, wheezing, or swelling of the mouth or throat), however, can be extremely dangerous and always require immediate medical attention.
What Your Pharmacist Wishes You Knew About Chronic Pain Medications

Pegloticase Drug Information

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