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Pegloticase

When and How to Receive This Medication

Some general considerations include the following:
 
  • This medication is given intravenously (by IV) once every two weeks.
     
  • You should be given medications such as a corticosteroid and an antihistamine before each dose of pegloticase to help prevent allergic reactions and "infusion reactions." Some examples of these reactions may include:
     
    • Hives
    • Itching
    • Shortness of breath
    • Chest pain.
 
  • The IV is given over a period of at least two hours. If you appear to be developing an infusion reaction, your healthcare provider may slow the IV down or may stop it altogether.
     
  • For the medication to work properly, it must be used as prescribed.
     

Storage Information

Pegloticase vials must be carefully stored in their cartons (to protect from light) under refrigeration. They should never be frozen or shaken; shaking this medicine can destroy the delicate pegloticase molecules.
 
Your healthcare provider must dilute pegloticase before administering it through an IV. Once diluted, the IV can be stored at room temperature or under refrigeration for up to four hours (refrigeration is preferred). However, it should be allowed to reach room temperature before being given by IV.
 

Is There a Generic Version?

This medication is not available in generic form (see Generic Krystexxa).
 

Who Makes Pegloticase?

Pegloticase is made by Savient Pharmaceuticals, Inc.
 
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Pegloticase Drug Information

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