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What If I Receive an Overdose of Pegloticase?

It is unknown what exactly to expect from receiving too much of this medication. Typically, an overdose is unlikely, as it is administered by your healthcare provider and because an entire vial contains a single dose.
(Click Krystexxa Overdose for more information.)

What Should I Do If I Miss a Dose?

If you fail to receive a dose of pegloticase on schedule, contact your healthcare provider to set up an appointment for your next dose right away.

How Does This Medication Work?

Pegloticase works by lowering uric acid levels. This helps to treat gout, as this condition occurs when the levels of uric acid become so high that uric acid crystals form inside the joint. The medication lowers uric acid levels by causing a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.
Pegloticase works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, pegloticase is usually given along with other gout medications, at least temporarily.

Effects of Pegloticase

Studies have shown that pegloticase lowers uric acid levels in the blood more effectively than a placebo (in this case, an IV fluid that does not contain any active ingredients). For instance, one study looked at the percentage of people who were able to lower their uric acid levels to 6 mg/dL or lower. In this study, 47 percent of people who received pegloticase every two weeks achieved this goal, compared to 0 percent of people who were given the placebo.
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Pegloticase Drug Information

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