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Pegloticase Dosage

The standard dosage of pegloticase for preventing gout attacks is 8 mg administered intravenously once every two weeks. Before receiving this infusion, you should also receive a corticosteroid and an antihistamine medication to help prevent potentially serious reactions, such as shortness of breath or chest pain. Also, you may need to take other medications to help prevent gout flares when first starting pegloticase.

An Introduction to Your Dosage of Pegloticase

There is only one standard dose of pegloticase (Krystexxa®), regardless of your age or weight. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Pegloticase Dosing for Gout

The recommended pegloticase dosage is 8 mg given intravenously (by IV) once every two weeks. You should be given medications such as a corticosteroid and an antihistamine before each dose of pegloticase to help prevent allergic reactions and "infusion reactions." Some of these reactions may include:
  • Hives
  • Itching
  • Shortness of breath
  • Chest pain.
Because pegloticase can cause gout flares, it is recommended that you take colchicine (Colcrys®) or a nonsteroidal anti-inflammatory drug (NSAID) starting one week before the first dose and continuing for at least six months, unless there is a medical reason you should not take such medications.

General Information on Receiving Pegloticase

Some considerations for people receiving pegloticase include the following:
  • The IV is given over a period of at least two hours. If you appear to be developing an infusion reaction, your healthcare provider may slow the IV down or may stop it altogether.
  • Because infusion reactions can be slow to develop, your healthcare provider may want to monitor you for an hour after each dose.
  • For the medication to work properly, it must be used as prescribed.
  • If you are unsure about anything related to pegloticase or your dosage of pegloticase, please talk with your healthcare provider, nurse, or pharmacist.
Alternative Therapies for Pain Management

Pegloticase Drug Information

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