Drug Interactions With Pegloticase

Theoretically, it may be possible for pegloticase to react with certain "PEGylated" medications, such as Adagen, Doxil, and Somavert. However, no studies have been done to determine specific drug interactions with pegloticase. Even though no specific interactions are known, make sure your healthcare provider is aware of any other medications you are taking, including nonprescription medicines.

An Overview of Pegloticase Interactions

Pegloticase (Krystexxa®) is a prescription gout medication that is given intravenously (by IV). No drug-interaction studies have been done with pegloticase.
 
However, it is theoretically possible that pegloticase might possibly interact with "PEGylated" medications (drug molecules that have been attached to polyethylene glycol polymers). PEGylated medications include:
 
Pegloticase often stimulates the body to produce a certain type of antibody that might bind to other PEGylated medications. It is unknown what effect (if any) this might have on other PEGylated medications.
 

Final Thoughts

It is possible that not all drug interactions with pegloticase were discussed in this article.
 Therefore, you should talk with your pharmacist or healthcare provider about specific interactions that may apply to you. It is always a good idea to give your healthcare provider a complete list of all medications you are taking, including prescription drugs, nonprescription drugs, herbs, and supplements.
 
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD
 
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