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OxyContin Drug Interactions

There are a number of drugs that may interact with OxyContin. Problems may occur if the narcotic is taken together with medicines such as antihistamines, antidepressants, barbiturates, or muscle relaxants. Some interactions could increase your risk of side effects (such as drowsiness, confusion, memory loss, or difficulty breathing), while others can lead to more dangerous problems.

OxyContin Interactions: An Overview

OxyContin® (oxycodone ER) is a prescription pain medication that can potentially interact with a number of other medications, particularly other medications that cause sedation. Some of the medicines that may lead to drug interactions with OxyContin include (but are not limited to):
  • Alcoholic beverages (or other products that contain alcohol)
  • Alvimopan (Entereg®)
  • Antidepressants
  • Antihistamines (including many non-prescription cold, cough, allergy, motion sickness, and sleep medications)
  • Antipsychotic drugs, including (but not limited to):



  • Barbiturate medications, such as:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepine sedatives, such as:



  • Muscle relaxants, such as:



  • Monoamine oxidase inhibitors (MAOIs), including:



Warning: 10 Hidden Sources of Lactose

OxyContin Medication Information

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