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Side Effects of Oxycodone/APAP

Other Possible Side Effects of Oxycodone/APAP

Common side effects of oxycodone/APAP may include:
  • Nausea, with or without vomiting (taking oxycodone/APAP with food may help prevent nausea and vomiting)
  • Dizziness or lightheadedness
  • Drowsiness
  • Constipation
  • An unexplained, pleasant feeling (euphoria) or unpleasant feeling (dysphoria)
  • Itching.
Many people consider themselves allergic to oxycodone/APAP if they experience nausea and vomiting while taking it. However, this is a common side effect and does not indicate a true allergy. In many cases, this side effect goes away as a person continues to use oxycodone/APAP.
People also often assume that itching indicates an allergic reaction. However, itching is not always a sign of an allergy to oxycodone/APAP, especially if no other allergy symptoms occur. Opiates (such as the one in oxycodone/APAP) cause a release of histamine, which often causes itching unrelated to any allergy. Even though this probably is not an allergy, you should still report it to your healthcare provider, as there are medications available to help relieve the itching.
Less common oxycodone/APAP side effects include:
  • Low blood pressure (hypotension) or high blood pressure (hypertension)
  • Fatigue
  • Thirst
  • Headaches
  • Increased sweating
  • An irregular heart rhythm (arrhythmia)
  • Seizures
  • Dehydration
  • Indigestion or heartburn
  • Taste changes
  • Diarrhea
  • Dry mouth
  • Hearing loss
  • Ringing in the ears (tinnitus)
  • Low blood sugar (hypoglycemia) or high blood sugar (hyperglycemia)
  • Red eyes
  • Flushing (redness of the skin, especially the face).
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