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Precautions and Warnings With Oxycodone/APAP

Who Should Not Take Oxycodone/APAP?

You should not take oxycodone/APAP if you:
  • Are allergic to Percocet, Endocet, Magnacet, Roxicet, Tylox, oxycodone hydrochloride, acetaminophen, or any of the inactive components used to make the medication. Your healthcare provider or pharmacist has a list of the inactive ingredients. If you are allergic to other narcotics or opiates, you may also be allergic to oxycodone/APAP.
  • Have significant respiratory depression (slow or ineffective breathing due to a variety of causes) that is not treated.



  • Have high levels of carbon dioxide in the blood (hypercarbia).


  • Have a bowel obstruction (paralytic ileus).

Final Thoughts

There are a number of situations in which oxycodone/APAP should not be taken, as well as several precautions and warnings people should be aware of before starting the medication. However, it is possible that not all of the warnings or precautions were discussed in this article. Therefore, talk with your healthcare provider about the specific oxycodone/APAP warnings and precautions that may apply to you.
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