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Oxycodone/APAP Dosage

The oxycodone/APAP dosage you are prescribed will depend on various factors, such as how you react to the medication, the particular oxycodone/APAP product, and other medications you are currently taking. Because this drug contains acetaminophen, it is important to not take more than 4 g of acetaminophen total per day, as it can lead to liver failure.

Oxycodone/APAP Dosage: An Introduction

The dose of oxycodone/APAP (Endocet®, Magnacet™, Percocet®, Roxicet™, Tylox®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The particular oxycodone/APAP product
  • How you react to the drug
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Recommended Dosage for Pain

The recommended dose for Percocet 2.5/325 mg tablets and Magnacet 2.5/400 mg tablets is one or two tablets every six hours as needed for pain. For all the other strengths, the recommended dose is one tablet or capsule (or one teaspoonful, for the oral solution) every six hours as needed for pain. In some cases, such as for severe pain or for people who have become tolerant to Percocet, higher doses may be recommended, up to certain maximums. Refer to the following table for the maximum number of tablets per day:
Maximum Per Day
Endocet 5/325 mg
Magnacet 2.5/400 mg
Percocet 2.5/325 mg
Percocet 5/325 mg
Roxicet 5/325 mg
12 tablets (or 12 teaspoonfuls for Roxicet oral solution)
Magnacet 2.5/400 mg
Magnacet 5/400 mg
10 tablets
Endocet 7.5/325 mg
Endocet 7.5/500 mg
Magnacet 7.5/400 mg
Percocet 7.5/325 mg
Percocet 7.5/500 mg
Roxicet 5/500 mg
8 tablets or capsules
Endocet 10/325 mg
Endocet 10/650 mg
Magnacet 10/400 mg
Percocet 10/325 mg
Percocet 10/650 mg
6 tablets
Percocet contains acetaminophen. It is very important to limit the total dose of acetaminophen to 4 grams (4000 mg) a day or less. Higher doses increase the risk of serious liver damage. Make sure to watch for any other sources of acetaminophen, including other prescription pain relievers and many over-the-counter products, such as Tylenol®. To be safe, all other acetaminophen products should be avoided while you are taking oxycodone/APAP, unless you are extremely careful to limit your total acetaminophen use (from all sources added together) to 4 grams per day. The larger number of the oxycodone/APAP strength (for instance, 500 mg) is the acetaminophen content; the smaller number (for instance, 5 mg) is the oxycodone content.
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Oxycodone APAP Drug Information

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