Drug Interactions With Oxycodone/APAP

Several medications can cause dangerous drug interactions with oxycodone/APAP, including antidepressants, sleep medications, and barbiturates. These interactions could increase your risk of serious side effects, such as extreme drowsiness, confusion, and difficulty breathing. To avoid any serious complications, it is important that you talk to your healthcare provider about possible drug interactions that may apply to you.

Drug Interactions With Oxycodone/APAP: An Overview

Oxycodone/APAP (Endocet®, Magnacet™, Percocet®, Roxicet™, Tylox®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions include:
 
  • Alcohol
  • Anticholinergic medications, including but not limited to:
 
 
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Benzodiazepines, such as:
 
 
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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