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Drug Interactions With Oxycodone/APAP

Other Narcotics or Opiates
Use extreme caution when combining oxycodone/APAP with other narcotics or opiates, as serious side effects could occur. You should only use these medications together with your healthcare provider's approval and supervision.
Taking oxycodone/APAP in combination with a phenothiazine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. This combination of medications may also increase the risk of dangerously low blood pressure (hypotension). Talk to your healthcare provider before taking these medications together.
Sleep Medications
Oxycodone/APAP can cause significant drowsiness, and combining it with a sleep medication could lead to dangerous effects. In general, oxycodone/APAP should not be used in combination with sleep medications, unless your healthcare provider specifically recommends that you do so.
Zidovudine (Retrovir)
Oxycodone/APAP may decrease the level of zidovudine in your blood, perhaps making it less effective. Check with your healthcare provider before taking these medications together.

Final Thoughts on Drug Interactions With Oxycodone/APAP

It is possible that not all drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interaction with oxycodone/APAP that may apply to you.
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